PREPARATION OF MAYTANSINOID ANTIBODY CONJUGATES BY A ONE-STEP PROCESS
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United States of America Patent
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Issued Date -
May 16, 2024
app pub date -
Jul 14, 2023
filing date -
Mar 29, 2011
priority date (Note) -
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Abstract
The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a pH of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products. The second mixture is then optionally subjected to purification to provide a purified cell-binding agent cytotoxic agent conjugate.
First Claim
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
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IMMUNOGEN INC | 830 WINTER STREET WALTHAM MA 02451 |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
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LI, Xinfang | Newton, US | 13 | 189 |
# of filed Patents : 13 Total Citations : 189 | |||
WORFUL, Jared M | Pittsburgh, US | 8 | 149 |
# of filed Patents : 8 Total Citations : 149 |
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3.5 Year Payment | $1600.00 | $800.00 | $400.00 | Nov 16, 2027 |
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Full Text
- (A) 2.0 to 8.0 mol % of vinylidene fluoride,(B) 60.0 to 70.0 mol % of tetrafluoroethylene,(C) 35.0 to 25.0 mol % of perfluoro(lower alkyl vinyl ether) or perfluoro(lower alkoxy-lower alkyl vinyl ether), and(D) 0.2 to 3.0 mol % of a perfluoro unsaturated nitrile compound, and having a Mooney viscosity ML1+10(121° C.) of 65 to 110, as well as a vulcanizable fluorine-containing elastomer composition comprising said fluorine-containing elastomer and a bisamidoxime compound in an amount of 0.2 to 5 parts by weight based on 100 parts by weight of the fluorine-containing elastomer. A sealing material obtained by vulcanization-molding of the fluorine-containing elastomer has not only excellent compression set characteristics and plasma resistance, but also low adhesion to metal at a higher temperature, specifically 150° C.

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