PREPARATION OF MAYTANSINOID ANTIBODY CONJUGATES BY A ONE-STEP PROCESS

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United States of America Patent

APP PUB NO 20240156976A1
SERIAL NO

18352362

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Abstract

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The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a pH of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products. The second mixture is then optionally subjected to purification to provide a purified cell-binding agent cytotoxic agent conjugate.

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Patent Owner(s)

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IMMUNOGEN INC830 WINTER STREET WALTHAM MA 02451

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
LI, Xinfang Newton, US 13 189
WORFUL, Jared M Pittsburgh, US 8 149

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges26596611201 - 1011 - 200200040006000800010000120001400016000180002000022000240002600028000

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