ANTIBODIES AGAINST TDP-43 AND METHODS OF USING THE SAME
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United States of America Patent
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Issued Date -
May 9, 2024
app pub date -
Mar 10, 2022
filing date -
Mar 10, 2021
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Abstract
The present invention relates to antibodies, and antigen binding fragments thereof, that specifically bind to the pathological form of TDP-43, which characterizes various TDP-43 proteinopathies. The antibodies, and antigen binding fragments thereof, decrease TDP-43 aggregation observed under pathological conditions. The invention also relates to nucleic acids that encode, and to cells that express such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments in the diagnosis, treatment and prevention of TDP-43 proteinopathies.
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