MODIFIED HUMAN SERUM ALBUMIN-THIOREDOXIN FUSION BODY
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United States of America Patent
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Issued Date -
May 9, 2024
app pub date -
Mar 15, 2022
filing date -
Mar 16, 2021
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Abstract
Disclosed is a serum albumin-thioredoxin fusion body which is improved in the activity thereof and is stable with respect to the activity. The serum albumin-thioredoxin fusion body is provided, which is characterized in that the thioredoxin is a modified from in which at least a cysteine residue located at position 73 from the N-terminal of an amino acid sequence for the thioredoxin or located at a position equivalent to the position 73 is substituted by another amino acid residue. the modified serum albumin-thioredoxin fusion body is superior in the activity and stability thereof, is reduced in immunogenicity and has superior safety compared with a fusion body in which the thioredoxin is non-modified form.
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