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• 15 United States
• 10 France
• 8 Japan
• 7 China
• 5 Korea
• 2 Other

Patent Owner(s)

Patent Owner	Address
IONIS PHARMACEUTICALS INC	CALIFORNIA USA CALIFORNIA

International Classification(s)

• A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
• C12N:MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF

• [Classification Symbol]

• [Patents Count]

Inventor(s)

Inventor Name	Address	# of filed Patents	Total Citations
Freier, Susan M	San Diego, US	526	6555
Guo, Shuling	Carlsbad, US	33	56
Monia, Brett P	Encinitas, US	303	5836
Siwkowski, Andrew M	Carlsbad, US	55	1386

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Maintenance Fees

Fee	Large entity fee	small entity fee	micro entity fee	due date
3.5 Year Payment	$1600.00	$800.00	$400.00	Oct 25, 2027
7.5 Year Payment	$3600.00	$1800.00	$900.00	Oct 25, 2031
11.5 Year Payment	$7400.00	$3700.00	$1850.00	Oct 25, 2035

Fee	Large entity fee	small entity fee	micro entity fee
Surcharge - 3.5 year - Late payment within 6 months	$160.00	$80.00	$40.00
Surcharge - 7.5 year - Late payment within 6 months	$160.00	$80.00	$40.00
Surcharge - 11.5 year - Late payment within 6 months	$160.00	$80.00	$40.00
Surcharge after expiration - Late payment is unavoidable	$700.00	$350.00	$175.00
Surcharge after expiration - Late payment is unintentional	$1,640.00	$820.00	$410.00

Full Text

US Patent Application No: 2024/0132,885

MODULATION OF TRANSTHYRETIN EXPRESSION

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