BLOW-FILL SEALING METHOD FOR FILLING AND PACKAGING
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United States of America Patent
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Issued Date -
Apr 25, 2024
app pub date -
Oct 10, 2023
filing date -
Oct 10, 2023
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Abstract
A method of controlling a temperature of a biopharmaceutical product during blow-fill sealing, includes developing a model based on heat transfer mechanisms that incorporates the effects of the blow-fill sealing on the biopharmaceutical product, providing a parison to a blow-fill sealing machine for accepting the biopharmaceutical product during the blow-fill sealing, predicting a temperature of at least one the biopharmaceutical product, the parison, and a component of the blow-fill sealing machine at a stage in the blow-fill sealing, and adjusting a parameter of the blow-fill sealing machine to reduce damage to the biopharmaceutical product.
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