FUNCTIONALIZED 1,3-BENZENE DIOLS AND THEIR METHOD OF USE FOR THE TREATMENT OF INFLAMMATION AND PAIN
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United States of America Patent
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Issued Date -
Apr 25, 2024
app pub date -
Jan 31, 2022
filing date -
Jan 31, 2022
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Abstract
A method of treating or preventing inflammation and pain includes administering to a subject a functionalized 1,3-benzene diol represented by a formula selected from formulas (I)-(X) as defined herein, and hydrates, solvates, pharmaceutically acceptable salts, and complexes thereof. Further disclosed is a chemotherapeutic method, including administering to a patient: (1) at least one chemotherapeutic agent and (2) at least one functionalized 1,3-benzene diol represented by a formula selected from formulas (I)-(X) as defined herein, and hydrates, solvates, pharmaceutically acceptable salts, and complexes thereof, which is effective to treat or prevent inflammation and pain associated with administering the at least one chemotherapeutic agent. A chemotherapeutic composition includes a chemotherapeutic agent selected from the group consisting of vincristine, vinblastine, paclitaxel, docetaxel, bortezomib, cisplatin, oxaliplatin and carboplatin, and a functionalized 1,3-benzene diol represented by a formula selected from formulas (I)-(X) as defined herein, and hydrates, solvates, pharmaceutically acceptable salts, and complexes thereof.
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