METHODS AND KITS FOR DETECTING A RISK FOR DEVELOPING NEUROLOGICAL OR NEUROPHYSIOLOGICAL DISORDERS

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United States of America Patent

APP PUB NO 20240117432A1
SERIAL NO

18270409

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention is based on the detection of microRNA (miR) in biological samples derived from subjects for assessing a risk that the subject develops a neurological and/or neuropsychological condition. The invention in particular detects the presence or absence and the amount of microRNA-181a-5p, microRNA146a-5p and/or microRNA148a-3p in such samples, which are shown by the invention to be associated with the neurological and/or neuropsychological condition. In addition, the invention provides a therapeutic application for the treatment of the neurological and/or neuropsychological condition by modulating the expression/function of these miR. Furthermore, the invention provides a method for monitoring the treatment success of the neurological and/or neuropsychological condition.

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Patent Owner(s)

Patent OwnerAddress
DEUTSCHES ZENTRUM FÜR NEURODEGENERATIVE ERKRANKUNGEN E V (DZNE)VENUSBERG-CAMPUS 1 GEBÄUDE 99 BONN 53127

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
FISCHER, Andre Göttingen, DE 22 157
ISLAM, Rezaul Göttingen, DE 1 0
SANANBENESI, Farahnaz Göttingen, DE 1 0

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