FACTOR B PROTEASES

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United States of America Patent

APP PUB NO 20240117334A1
SERIAL NO

18219384

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided herein are engineered proteases of the S1A family that are specific for, and capable of, cleaving Factor B. Also provided herein are methods of making and using such engineered proteases. The engineered proteases provided herein may be useful for treating a disease or condition associated with dysregulation of the complement system by reducing complement activation through cleavage and inactivation of Factor B.

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Patent Owner(s)

Patent OwnerAddress
VERTEX PHARMACEUTICALS INCORPORATED50 NORTHERN AVENUE 15TH FLOOR BOSTON MA 02210

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BLOUSE, Grant E Burlingame, US 7 3
LE, MOAN Natacha San Francisco, US 15 9
MYLES, Timothy South San Francisco, US 8 3
POPKOV, Mikhail San Diego, US 19 533
SOROS, Vanessa San Francisco, US 17 20

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