DEVICES AND METHODS FOR MODULATING IMMUNE SYSTEM ACTIVITY IN A CANCER PATIENT AND TREATING CANCER

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United States of America Patent

APP PUB NO 20240100327A1
SERIAL NO

17767409

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Described herein are methods and devices for monitoring or modulating an immune system in a subject with cancer, and methods and devices for treating a cancer in a subject. The implanted device can electrically stimulate the splenic nerve of the subject, which can modulate the inflammatory system (for example, by increasing or decreasing the blood level of one or more pro-inflammatory cytokines and/or anti-inflammatory cytokines to increase or decrease inflammation in the subject) and/or activate or increase circulation of one or more immune cells (such as natural killer cells and/or cytotoxic T-cells), for the treatment of cancer. The implanted medical device includes two or more electrodes configured to electrically stimulate the splenic nerve, and may further include an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device.

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Patent Owner(s)

Patent OwnerAddress
IOTA BIOSCIENCES INC1020 ATLANTIC AVENUE SUITE 100 ALAMEDA CA 94501

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CARMENA, Jose M Alameda, US 32 448
KAY, Joshua Oakland, US 10 72
MAHARBIZ, Michel M El Cerrito, US 41 465
MONTERO, GARNIER Giana Berkeley, US 3 8
NEELY, Ryan El Cerrito, US 17 202

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