T CELL RECEPTORS AND FUSION PROTEINS THEREOF
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United States of America Patent
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Mar 21, 2024
app pub date -
Aug 17, 2023
filing date -
Aug 18, 2022
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Abstract
The present disclosure provides T cell receptor (TCR) fusion proteins comprising a TCR that binds to a GVYDGREHTV (SEQ ID NO:34) HLA-A*02 complex that is covalently linked to a T cell engaging domain that binds a protein expressed on a cell surface of a T cell and an antibody Fc domain, as well as polynucleotides, vectors, kits, host cells, pharmaceutical compositions, methods, and uses related thereto.
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