PREPARATION OF FUNCTIONAL HOMOCYSTEINE RESIDUES IN POLYPEPTIDES AND PEPTIDES

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United States of America Patent

APP PUB NO 20240092833A1
SERIAL NO

18235184

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methodology was developed for transformation of methionine residues into homocysteine derivatives. Methionine residues can undergo alkylation reactions at low pH to yield sulfonium ions, which can then be selectively demethylated to give alkyl homocysteine residues. This process tolerates many functional groups.

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Patent OwnerAddress
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA1111 FRANKLIN STREET TWELFTH FLOOR OAKLAND CA 94607-5200

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Deming, Timothy J Los Angeles, US 31 533
Gharakhanian, Eric G Los Angeles, US 7 8

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