NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR

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United States of America Patent

APP PUB NO 20240092819A1
SERIAL NO

18248988

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Abstract

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The present disclosure provides novel piperidine- and guanosine-derived ligands that bind specifically to asialoglycoprotein receptor (ASGPR) and nucleotide analogs conjugated thereto that can be incorporated into oligonucleotides, including double-stranded oligonucleotides such as siRNAs.

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Patent OwnerAddress
SANOFI SA46 AVENUE DE LA GRANDE ARMEE PARIS 75017 FR

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
ELSHORST, Bettina Frankfurt am Main, DE 1 0
HESSLER, Gerhard Frankfurt am Main, DE 35 450
HOFMEISTER, Armin Frankfurt am Main, DE 58 469
LI, Ziyu Frankfurt am Main, DE 16 97
PÖVERLEIN, Christoph Frankfurt am Main, DE 5 2
SCHREUDER, Herman Frankfurt am Main, DE 30 64
ZECH, Gernot Frankfurt am Main, DE 8 19

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