AMLODIPINE DRY SUSPENSION AND PREPARATION METHOD THEREFOR
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United States of America Patent
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Issued Date -
Mar 14, 2024
app pub date -
Dec 31, 2021
filing date -
Jan 18, 2021
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Abstract
An amlodipine dry suspension, comprising a diluent, a suspending aid, etc. and being free of surfactants. A preparation method therefor comprises the following steps: a) preparing an aqueous mixture 1 containing amlodipine besylate by using a high-speed homogenization method; b) adding sodium benzoate to the mixture 1, and homogenizing same at a high speed to obtain a mixture 2; and c) granulating the mixture 2 and other components, and then drying same. The raw materials are homogenized and mixed at a high speed, no surfactant is added during the preparation, amlodipine is fully wetted by using a high-speed homogenization process, prescription components are simplified, and the amlodipine dry suspension is more suitable for children to use. Compared with ultrasonic stirring, scaled-up and industrial production are easier to realize for the high-speed homogenization process, and at the same time, the preparation is good in stability and convenient to carry.
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