APPARATUS AND METHOD FOR CRYOGRANULATING A PHARMACEUTICAL COMPOSITION

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20240074976A1
SERIAL NO

18500199

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium. Methods of cryogranulating the pharmaceutical substance in the fluid medium are also provided. In particular embodiments, the dispenser assembly is used with suspensions or slurries of pharmaceutical compositions including biodegradable substances, such as proteins, peptides, and nucleic acids. In certain embodiments, the pharmaceutical substance can be adsorbed to any pharmaceutically acceptable carrier particles suitable for making pharmaceutical powders. In one embodiment, the pharmaceutical carrier can be, for example, diketopiperazine-based microparticles. The dispenser assembly improves the physical characteristics of the cryopellets formed and minimizes product loss during processing.

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Patent Owner(s)

Patent OwnerAddress
MANNKIND CORPORATION30930 RUSSELL RANCH ROAD SUITE 301 WESTLAKE VILLAGE CA 91362

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Amoro, Edwin West Haven, US 7 21
Vanackere, Karel Knokke-Heist, BE 7 21
White, Michael A Brookfield, US 23 464

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