Importance

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Abstract

The disclosure relates to lipid-coated calcium carbonate nanoparticles, said nanoparticles comprising an outer layer and a core being calcium carbonate nanoparticle, wherein said core is vaterite, proto-vaterite, or amorphous calcium carbonate as determined by X-Ray diffraction, wherein said core is at least partially coated with one or more amphiphilic compounds each having one hydrophilic head and at least one hydrophobic tail, remarkable in that the hydrophilic heads are negatively charged and form the outer layer of the nanoparticles, in that the nanoparticles have a surface charge having a ζ-potential below 0 mV as determined by micro-electrophoretic light scattering technology and in that said one or more amphiphilic compounds are PEG-free. The disclosure also relates to methods for forming such nanoparticles, for modulating the electrical charge of such nanoparticles as well as to the uses of such nanoparticles.

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First Claim