DRIED CELL SECRETOME-BASED THERAPEUTIC AGENT FOR OSTEOARTHRITIS TREATMENT
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United States of America Patent
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Issued Date -
Feb 29, 2024
app pub date -
Jan 10, 2022
filing date -
Jan 8, 2021
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Abstract
The present invention relates to a method for producing a culture medium-derived component or a crystallized culture medium using a PCA (Precipitation with Compressed Fluid Anti-solvent) drying process, a method for restoring chondrocytes using the culture medium-derived component or the crystallized culture medium prepared by way of the above method, a method for treating a subject having osteoarthritis by way of the method for restoring chondrocytes using the culture medium-derived component or the crystallized culture medium, a method for treating a subject having osteoarthritis using the culture medium-derived component or the crystallized culture medium, and the use of the culture medium-derived component or the crystallized culture medium for the treatment of osteoarthritis. The culture medium-derived component provided in the present invention has excellent activity of alleviating inflammatory environment and inhibiting expression of catabolism-related genes, and the culture medium-derived component can be produced in a higher yield by way of the method provided in the present invention, and thus can be widely used in the development of therapeutic agents for osteoarthritis.
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