TRANSFERRIN RECEPTOR BINDING PROTEINS AND CONJUGATES
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United States of America Patent
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Issued Date -
Feb 22, 2024
app pub date -
Aug 7, 2023
filing date -
Aug 8, 2022
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Abstract
Provided herein are proteins comprising one monovalent human TfR binding domain (“human TfR binding proteins”), proteins comprising one monovalent mouse TfR binding domain (“mouse TfR binding proteins”), conjugates comprising such human or mouse TfR binding proteins, e.g., human TfR binding proteins-dsRNA conjugates, pharmaceutical compositions comprising human TfR binding proteins or conjugates, and methods of treating CNS diseases (e.g., neurodegenerative disease such as neurodegenerative synucleinopathy or tauopathy) using human TfR binding proteins or conjugates.
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