HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20240059703A1
SERIAL NO

18032548

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided are compounds of Formula (I) having activity as inhibitors of G12C mutant KRAS protein, pharmaceutical compositions comprising the compounds, and uses and methods of treating certain disorders, such as cancer, including but not limited to lung, pancreatic and colorectal cancers.

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Patent Owner(s)

Patent OwnerAddress
AMGEN INC1 AMGEN CENTER DR THOUSAND OAKS CA 91320

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BANERJEE, ABHISEK BANGALORE, KARNATAKA, IN 27 164
CHU-MOYER, MARGARET BROOKLINE, US 5 77
DAI, DONGCHENG CORVALLIS, US 63 518
ESHON, JOSEPHINE ITHACA, US 2 0
HUANG, DAVID THOUSAND OAKS, US 189 5429
KALLER, MATTHEW R VENTURA, US 32 278
LANMAN, BRIAN ALAN WOODLAND HILLS, US 48 620
LEE, HEEJUN THOUSAND OAKS, US 47 192
LOPEZ, PATRICIA WOODLAND HILLS, US 69 1004
MA, VU VAN OAK PARK, US 33 488
MANONI, FRANCESCO NEWBURY PARK, US 9 1
MEDINA, JOSE M THOUSAND OAKS, US 5 1
PICKRELL, ALEXANDER J WESTLAKE VILLAGE, US 38 337
STELLWAGEN, JOHN C NEWBURY PARK, US 3 12
SUN, ZHEN SHANGHAI, CN 74 234
TAMAYO, NURIA A NEWBURY PARK, CA 40 502
ZHANG, WENHAN THOUSAND OAKS, US 24 143
ZHU, KAI WESTLAKE VILLAGE, US 125 456

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