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United States of America Patent
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Issued Date -
Feb 8, 2024
app pub date -
Dec 13, 2021
filing date -
Dec 11, 2020
priority date (Note) -
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Abstract
Provided herein are Cas9 proteins comprising SEQ ID NO:1 or a sequence at least 80% identical thereto, wherein: the amino acid residues at positions 765 to 780 are replaced by the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6; the amino acid residues at positions 838 to 853 are replaced by the amino acid sequence of SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9 or SEQ ID NO:10; and/or the amino acid residues at positions 911 to 925 are replaced by the amino acid sequence of SEQ ID NO:11, SEQ ID NO:12 or SEQ ID NO:13. Also provided are Cas9 proteins comprising an HNH domain comprising the amino acid sequence of SEQ ID NO:14 or a sequence at least 80% identical thereto, wherein: the amino acid residues at positions 1 to 16 are replaced by the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6; the amino acid residues at positions 74 to 89 are replaced by the amino acid sequence of SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9 or SEQ ID NO:10; and/or the amino acid residues at positions 147 to 161 are replaced by the amino acid sequence of SEQ ID NO:11, SEQ ID NO:12 or SEQ ID NO:13.
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