Smart exosomes for active PDAC targeting and evading mononuclear phagocytotic system

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United States of America Patent

PATENT NO 12090213
APP PUB NO 20240042055A1
SERIAL NO

18550503

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Abstract

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Exosomes that express peptides in CD9 proteins, and smart exosomes that co-express two peptides incorporated into CD9 proteins to home delivery of the exosomes to a desired target and evade phagocytosis by macrophages, are described. Provided are exosomes useful for delivering drugs to desired targets. The exosomes comprise drugs, such as chemotherapeutic drugs, encapsulated in their core. The targets include pancreatic cancer cells.

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Patent Owner(s)

Patent OwnerAddress
THE UNIVERSITY OF TOLEDO2801 W BANCROFT STREET TOLEDO OH 43606-3390

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brunicardi, Francis Charles Toledo, US 5 0
Liu, Shi-He Toledo, US 7 1

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