Compositions and Methods For Inhibiting FGF23 Activity
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United States of America Patent
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Feb 1, 2024
app pub date -
Sep 2, 2021
filing date -
Sep 3, 2020
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Abstract
The present disclosure provides in one aspect a construct comprising the R2 region of FGF23. In other embodiments, the construct functions as a FGF23 antagonist by blocking FGF23 binding to α-Klotho and cell signaling via FGFR activation. In yet other embodiments, the construct prevents FGFR activation. In yet other embodiments, the construct of the present disclosure can be used to treat diseases or disorders related to FGF23 dysregulation and/or overexpression, such as but not limited to phosphate metabolism disorders.
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