IMIDAZOLE COMPOUNDS AS INHIBITORS OF ENPP1
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United States of America Patent
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Issued Date -
Feb 1, 2024
app pub date -
Dec 1, 2021
filing date -
Dec 2, 2020
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Abstract
Compounds having activity as inhibitors of ENPP1 are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, stereoisomer, or prodrug thereof, wherein L, R1, R2a, R2b, R2c, R2d, R2e and n are as defined herein. This disclosure provides methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds, and methods for treating disorders associated with ENPP1, including uncontrolled cellular proliferation, cancer and virial or bacterial infections in a mammal.
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