Method for multi-dimensional analysis of cell epigenomics
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United States of America Patent
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Jan 18, 2024
app pub date -
Sep 16, 2020
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Sep 16, 2020
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Abstract
A method for analyzing cell epigenomics from multiple dimensions. The method comprises the following steps: by using ChiTag transposase and conventional Tn5 transposase in cells, respectively embedding different linker sequences, and achieving common analysis of information of a chromatin open region and information of a specific protein binding sequence on a cellular level. The method has important application prospects in aspects such as study of development and/or disease related cell population heterogeneity, drawing of a cell map, analysis of tumor cells having different clinical characteristics, and clinical study of evolution and/or metastasis of tumor cells.
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