SOLID DISPERSION, PHARMACEUTICAL PREPARATIONS, PREPARATION METHOD, AND APPLICATION THEREOF
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United States of America Patent
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Issued Date -
Jan 18, 2024
app pub date -
Nov 25, 2021
filing date -
Nov 25, 2020
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Abstract
The invention discloses a solid dispersion, a pharmaceutical preparation, a preparation method and an application thereof. The solid dispersion of the invention comprises carriers and active constituents, which is a compound as shown in formula (I) and/or a pharmaceutically acceptable salt thereof; The carrier is “homopolymer and copolymer of N-vinyl lactam” and/or pH-dependent cellulose derivatives. The preparation of the invention comprises the solid dispersion, fillers and disintegrating agents. The solid dispersion of the invention has good dissolution and significantly improves the solubility of effective constituents. The preparation can effectively improve the bioavailability of Bcl-2 inhibitor, has good dissolution and stability, and can improve the safety of a medication.
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