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Abstract

The disclosure relates to methods, systems, kits and probe sets for the identification, determination, diagnosis, and/or prognosis of homologous recombination deficiency prostate cancer in a subject. The disclosure also provides biomarkers and clinically useful genomic classifiers for identifying homologous recombination deficiency prostate cancer, bioinformatic methods for determining clinically useful classifiers, and methods of use of each of the foregoing. The methods, systems, kits and probe sets can provide expression-based analysis of biomarkers for purposes of homologous recombination deficiency prostate cancer in a subject. Methods of treating homologous recombination deficiency prostate cancer based on expression analysis are also provided. The methods and classifiers of the present disclosure are also useful for predicting response to anticancer therapy (e.g., PARP inhibitors).

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First Claim