SUSTAINED-RELEASE ANESTHETIC COMPOSITIONS AND METHODS OF PREPARATION THEREOF

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United States of America Patent

APP PUB NO 20240000764A1
SERIAL NO

18466226

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided is an anesthetic composition for locally administrating an amide-type anesthetic into a subject in need thereof. The anesthetic composition has multilamellar vesicles with entrapped amide-type anesthetic prepared by hydrating a highly entrapped lipid structure comprising an amide-type anesthetic and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more feasible process for large-scale manufacture and for providing a high molar ratio of amide-type anesthetic to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.

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Patent OwnerAddress
TLC BIOPHARMACEUTICALS INCTAIPEI

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
GUO, Luke SS San Francisco, US 13 47
HONG, Keelung San Francisco, US 78 966
KAO, Hao-Wen Taipei City, TW 14 7
LIN, Yi-Yu Taipei City, TW 32 31

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