CELL-PENETRATING PEPTIDES

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United States of America Patent

APP PUB NO 20230416334A1
SERIAL NO

18036329

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Abstract

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The present invention provides a peptide of a length from 10 to 50 amino acid residues, which comprises the amino acid sequence Xaa1KXaa2WXaa3Xaa4Xaa5Xaa6Xaa7W (SEQ ID NO: 1), wherein Xaa1, Xaa2 Xaa3, Xaa4 Xaa5, Xaa6 and Xaa7 are each independently any amino acid, in particular, which comprises the amino acid sequence LKXaa1WXaa2Xaa3GAIW (SEQ ID NO: 19), wherein Xaa1, Xaa2, and Xaa3, are each independently any amino acid. The invention also provides a conjugate comprising the peptide, a pharmaceutical composition comprising the conjugate, a method for delivering a cargo into a cell, a nucleic acid molecule encoding the peptide, and a host cell comprising said nucleic acid molecule.

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Patent Owner(s)

Patent OwnerAddress
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON-INSTITUT DE RECERCABARCELONA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DA, SILVA ANDRADE Fernanda Raquel BARCELONA, ES 1 0
FERNANDES, DE SOUSA RAFAEL Diana BARCELONA, ES 1 0
MARTÍNEZ, BARRIOCANAL Águeda BARCELONA, ES 1 0
SAYÓS, ORTEGA Juan BARCELONA, ES 1 0
SCHWARTZ, NAVARRO Simón SABADELL, ES 5 4
SERAS, FRANZOSO Joaquin MATARÓ, ES 1 0

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