LOW-DOSE HEPATOCYTE GROWTH FACTOR GENE THERAPY FOR DIABETES
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United States of America Patent
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Issued Date -
Dec 28, 2023
app pub date -
Nov 18, 2021
filing date -
Nov 18, 2021
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Abstract
An agent for protecting and/or regenerating pancreatic β cells in a mammal with diabetes, containing a recombinant viral vector expressing a hepatocyte growth factor (HGF), wherein the agent is administered at a dose of 1010-1012 virus particles (vp)/kg body weight, and the viral vector contains a nucleic acid encoding HGF downstream of a promoter with transcriptional activity capable of affording a therapeutically effective blood HGF level at said dose is provided by the present invention.
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