METHOD FOR GRADING THE NUCLEAR MORPHOLOGY OF A TUMOR
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United States of America Patent
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Dec 21, 2023
app pub date -
Nov 10, 2021
filing date -
Nov 10, 2020
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Abstract
The present invention relates to a method of grading the nuclear morphology of a tumor cell. The method may comprise a) culturing the tumor cell on an array comprising a plurality of nanopillars; and b) assessing a deformation pattern of the nucleus, wherein an isotropic deformation indicates low malignancy of the tumor cell, while a linear or anisotropic deformation pattern indicates high malignancy of the tumor cell. In another embodiment, the method comprises determining a nanopillar-induced deformation profile comprising an angular distribution of orientations in a plurality of regions of interests (ROIs) of the image and a coherency in each ROI. The invention also relates to a method of predicting the likelihood of a metastatic cancer or predicting a response of a tumor to a cancer drug in a subject based on assessing the degree of nuclear deformation of a cell sample cultured on the surface comprising a plurality of nanopillars.
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