MOLECULAR DESIGNS OF GLUCOSE-RESPONSIVE AND GLUCOSE-CLEAVABLE INSULIN ANALOGUES
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United States of America Patent
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Issued Date -
Dec 14, 2023
app pub date -
Oct 22, 2021
filing date -
Oct 22, 2020
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Abstract
A two-chain insulin analogue is provided containing (a) a B chain modified by a C-terminal diol element such that one hydroxyl group substitutes for the C-terminal carboxylate function in combination with (b) a glucose-binding element attached to the A chain at or near its N terminus. Compositions comprising such insulin analogs are used in methods of treating a patient with diabetes mellitus.
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