Importance

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Abstract

Focused-ultrasound systems and methods involve simultaneously determining multiple ultrasound parameters (e.g., applied acoustic power, frequency, phases, position, activation pattern, beam shape, wave shape, etc.) associated with the transducer array for generating optimal treatment effects both at the target region (e.g., causing a sufficient temperature increase for tissue necrosis to occur) and non-target region (e.g., having a clinically insignificant temperature increase to avoid damage to the non-target tissue). A computational model may simulate the treatment effects (e.g., the temperature, peak intensity, focus shape, location of the hot spot, etc.) of these ultrasound parameters on the target and/or non-target regions. Based on the simulation results, the computational model may simultaneously determine the optimal values of the multiple ultrasound parameters—i.e., the values that, while not necessarily optimal for each individual parameter considered in isolation, nonetheless produce optimal overall treatment effects at the target and non-target

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First Claim