SYNTHESIS AND USES OF GINSENOSIDE COMPOUND K DERIVATIVES
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Nov 30, 2023
app pub date -
May 11, 2023
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May 31, 2022
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Abstract
A nontoxic anticancer compound is a derivative of 20-O-β-(D-glucopyranosyl)-20(S)-protopanaxadiol (CK) having at least one of the glucose hydroxyl groups replaced with at least one acetal group. The derivative enhances binding to a mitochondrial membrane protein and is more cytotoxic to cancerous cells than CK. The derivative can be an acetal of an unsubstituted or substituted aromatic group, such as an acetal formed from a substituted 1-(dimethoxymethyl)-benzene. One or more of the CK derivative (CKD) anticancer compounds can be used as an active portion of an anticancer medicament.
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