OLIGONUCLEIC ACID CONJUGATE
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United States of America Patent
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Issued Date -
Nov 23, 2023
app pub date -
Oct 8, 2021
filing date -
Oct 9, 2020
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Abstract
An object of the present invention is to increase an amount of oligonucleotide transported into cytoplasm by allowing a cellular internalization enhancer to efficiently interact with target cells. An oligonucleotide conjugate according to the present invention contains a dendritic polymer, a plurality of oligonucleotides, one or a plurality of cellular internalization enhancers, and one or a plurality of hydrophilic linkers, wherein each oligonucleotide is bonded to the dendritic polymer directly or through a linker, and each cellular internalization enhancer is bonded to the dendritic polymer through the hydrophilic linker.
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