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Abstract

Benzodiazepine derivatives of formula (Ib) wherein: R¹ is H or halo; Y is selected from O, S, SO, SO₂ and NR; one or two of V, W and X is or are N or CH and the other one or two is or are CH; R² is a group selected from C₁-C₆ alkyl, C₁-C₆ hydroxyalkyl, C₁-C₆ haloalkyl, halo, —OR, —NHR″, —SO_mNR₂, —SO_mR, nitro, —CO₂R, —CN, —CONR₂, —NHCOR and —NR¹¹R¹²; each R is independently H or C₁-C₆ alkyl; R¹¹ and R¹² are each independently H or C₁-C₆ alkyl; or R¹¹ and R¹² form, together with the N atom to which they are attached, either (a) a morpholine ring which is optionally bridged by a —CH₂— group linking two ring carbon atoms that are positioned para to each other, or (b) a spiro group of the following formula (b): R″ is C₃-C₆ cycloalkyl; m is 1 or 2; n is 0, 1 or 2; and each of R³ to R¹⁰ is independently selected from H, C₁-C₆ alkyl, halo, —OR, -NR₂,—NHR″, —SO_mNR₂, —SO_mR, nitro, —CO₂R, —CN, —CONR₂, —NHCOR, —NR¹³R ⁴ whereinR¹³ and R¹⁴ form, together with the N atom to which they are attached, a morpholine ring, and the following options (i) to (iii): (i) any two of R³ to R¹⁰ that bond to the same carbon atom form a C₃-C₆ spiro ring; (ii) any two of R³ to R¹⁰ that bond to non-adjacent carbon atoms form a C₁-C₃ bridgehead group linking the carbon atoms to which they are bonded; and (iii) any two of R³ to R¹⁰ that bond to adjacent carbon atoms form, together with the carbon atoms to which they are bonded, a C₃-C₆ cycloalkyl group; and wherein each alkyl group or moiety recited above is linear or branched; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

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First Claim