FXR SMALL-MOLECULE AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF

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United States of America Patent

APP PUB NO 20230357244A1
SERIAL NO

18029359

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Abstract

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A strong FXR small-molecule agonist, and a preparation method therefor and use thereof, the structure of the agonist being represented by formula (I), are provided. In the formula, each substituent is as defined in the description and the claims. The compound provided has the advantages of high FXR agonist activity, simple synthesis, easily available raw materials and the like, and can be used for preparing medicines for treating FXR related diseases.

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Patent Owner(s)

Patent OwnerAddress
SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES201203 555 ZHANGJIANG ROAD ZHANGJIANG PUDONG NEW AREA SHANGHAI SHANGHAI CITY SHANGHAI CITY 201203

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
GAO, Lixin Pudong Shanghai, CN 8 79
LI, Jia Pudong Shanghai, CN 426 6096
LIU, Mingliang Pudong Shanghai, CN 11 4
SHI, Jingjing Pudong Shanghai, CN 9 16
SUN, Dandan Pudong Shanghai, CN 15 7
TAN, Qian Pudong Shanghai, CN 8 14
XIE, Rongrong Pudong Shanghai, CN 5 5
XU, Huaqiang Pudong Shanghai, CN 9 3
YOU, Erli Pudong Shanghai, CN 2 1
ZANG, Yi Pudong Shanghai, CN 18 220

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