ENGINEERED ENZYMES AND METHODS OF MAKING AND USING
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United States of America Patent
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Issued Date -
Nov 2, 2023
app pub date -
Apr 23, 2021
filing date -
Apr 24, 2020
priority date (Note) -
Published
status (Latency Note)
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Abstract
The invention provides an engineered carboxylic acid reductase (CAR) enzyme, a nucleic acid encoding the CAR enzyme, and a non-naturally occurring microbial organism comprising an exogenous nucleic acid encoding the CAR, an engineered transaminase (TA) enzyme, and/or a hexamethylenediamine (HMD) transaminase (TA2) enzyme. The invention provides a non-naturally occurring microbial organism that has a 1,6-hexanediol (HDO) pathway with a HDO pathway enzyme expressed in sufficient amounts to produce 6 aminocaproate semi aldehyde, HDO, or both. The invention further provides a non-naturally occurring microbial organism that has an HMD pathway with a HMD pathway enzyme expressed in sufficient amounts to produce 6-aminocaproate semialdehyde, HMD, or both. The invention additionally provides bioderived HMD, 6-aminocaproate semialdehyde, and/or HDO and methods for producing bioderived HMD, 6-aminocaproate semialdehyde, and/or HDO.
First Claim
Other Claims data not available
Family
| Country | kind | publication No. | Filing Date |
|---|---|---|---|
| WO | A2 | WO2021216952 | Apr 23, 2021 |
| KR | A | KR20230003072 | Apr 23, 2021 |
| EP | A2 | EP4139444 | Apr 23, 2021 |
| CN | A | CN116096869 | Apr 23, 2021 |
International Classification(s)
- 2021 Application Filing Year
- C12P Class
- 1408 Applications Filed
- 425 Patents Issued To-Date
- 30.19 % Issued To-Date
Cited Art Landscape
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- C12P Class
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