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Abstract

The present invention pertains to a new method for the prognosis, diagnosis, stratification and/or monitoring of a therapy of a disorder in a subject. The method is based on the determination of the level of at least one first biomarker indicative and/or selective for the status and/or activity of the pathway regulating N6-methyladenosine (m6A) mRNA modification, and the determination of the level, mutation status, and/or activity of at least one second biomarker indicative and/or selective for the status and/or activity of the pathway regulating 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U)-tRNA modification as combined biomarkers. The new biomarkers of the invention allow diagnosing and even stratifying of a disorder in a patient, estimating a patient's prognosis, and monitoring therapy success of patients, in particular of cancer patients, such as breast cancer patients. Further provided are kits for the prognosis, diagnosis, and/or monitoring of a disease, condition or disorder in a subject. The invention also pertains to a compound for use in the treatment of a disease, condition or disorder, wherein the compound specifically reduces or enhances the level, mutation status, and/or activity of a gene, mRNA or protein regulating m6A mRNA modification in a cell, and/or a gene, mRNA or protein regulating mcm5s2U-tRNA modification in a cell.

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First Claim