METHODS FOR INTRACELLULAR DELIVERY AND ENHANCED GENE TARGETING

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United States of America Patent

APP PUB NO 20230340480A1
SERIAL NO

18187524

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed herein are methods and compositions for enhancing gene targeting. The method entails co-administrating to a cell a targeting molecule and a means of enhancing the function of the targeting molecule upon delivery to the cell. The means of enhancing the function of the targeting molecule including one or more of a stressor that induces cellular stress, a proton sponge molecule, and an endosome or lysosome inhibitor. Compositions disclosed include a targeting molecule and one or more of a stressor that induces cellular stress, a proton sponge molecule, and an endosome or lysosome inhibitor.

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Patent Owner(s)

Patent OwnerAddress
CITY OF HOPE1500 EAST DUARTE ROAD DUARTE CA 91010-3000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CASTANOTTO, Daniela Altadena, US 11 58
STEIN, Cy La Canada Flintridge, US 11 1855
ZHANG, Xiaowei Duarte, US 201 429

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