COMPOSITE MAGNETIC NANOMATERIAL BASED ON DNA TETRAHEDRON, PREPARATION THEREFOR AND USE THEREOF
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United States of America Patent
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Issued Date -
Oct 19, 2023
app pub date -
Jun 20, 2023
filing date -
Jan 19, 2021
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Abstract
A composite magnetic nanomaterial based on a DNA tetrahedron, preparation therefor and use thereof are provided. The preparation method include the steps of synthesizing a DNA tetrahedron by means of a self-assembly reaction of single-stranded DNA chains, loading magnetic nanoparticles on the surfaces of molybdenum disulfide particles, modifying gold nanoparticles on exposed active sulfur atoms of the molybdenum disulfide particles, modifying the DNA tetrahedron on the gold nanoparticles, and bonding a protein antibody on the DNA tetrahedron. The composite magnetic nanomaterial is used for enriching and detecting low-abundance proteins in serum, and specific low-abundance proteins in the serum can be efficiently and selectively enriched by means of the specific reaction between an antigen and an antibody.
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