Kit and method for constructing long-acting depression animal model

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11963519
APP PUB NO 20230329200A1
SERIAL NO

17895405

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The present disclosure provides a kit and method for constructing a long-acting depression animal model. The present disclosure adopts Bacille Calmette-Guerin (BCG) (or Mycobacterium bovis (M bovis)) and low-dose pertussis toxin (PTX) for combined induction, which greatly reduces modeling cost. A mouse model constructed by the method of the present disclosure can clearly distinguish a time interval of pathological behaviors from a time interval of depression-like behaviors and has prominent face validity and predictive validity. The method of the present disclosure is simple and convenient and does not require a large number of tedious daily operations as the depression model construction by chronic unpredictable stress, chronic restraint stress, social defeat, mother-child separation, or the like. The mouse model of the present disclosure can provide a valuable long-term intervention window for research on antidepressant therapy.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
NORTHWEST INSTITUTE OF PLATEAU BIOLOGY CASQINGHAI

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bi, Hongtao Xining, CN 2 0
Chen, Zhanjuan Xining, CN 1 0
Du, Yuzhi Xining, CN 2 0
Li, Cen Xining, CN 11 36
Qiao, Yajun Xining, CN 1 0
Wang, Jianv Xining, CN 1 0
Wei, Lixin Xining, CN 6 3
Xiao, Yuancan Xining, CN 1 0
Yang, Hongxia Xining, CN 25 171
Zhao, Jing Xining, CN 323 1809

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Oct 23, 2027
7.5 Year Payment $3600.00 $1800.00 $900.00 Oct 23, 2031
11.5 Year Payment $7400.00 $3700.00 $1850.00 Oct 23, 2035
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00