Tandem Dyes Having Internally Positioned Sensors, and Methods for Making and Using the Same
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United States of America Patent
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Issued Date -
Oct 12, 2023
app pub date -
Mar 28, 2023
filing date -
Apr 6, 2022
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Abstract
Tandem dyes having internally positioned sensors are provided. Tandem dyes of embodiments of the invention include a peptidic scaffold comprising: one or more donor-fluor amino acid residues each conjugated to a pendant donor fluorophore; one or more acceptor-fluor amino acid residues each conjugated to a pendant acceptor fluorophore; and an internal amino acid residue conjugated to a sensor, e.g., a specific binding member, e.g., for a target analyte. In tandem dyes of embodiments of the invention, the donor and acceptor fluorophores of the are in energy transfer relationship. Also provided are methods of making and using the tandem dyes, as well as kits that include the dyes that find use in embodiments of the methods.
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