ANTIVIRAL SILENCING RNA MOLECULES, CHEMICALLY MODIFIED ANTIVIRAL SILENCING RNA MOLECULES WITH ENHANCED CELL PENETRATING ABILITIES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND USES THEREOF FOR TREATMENT OF VIRAL INFECTIONS
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United States of America Patent
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Issued Date -
Oct 12, 2023
app pub date -
Sep 3, 2021
filing date -
Sep 4, 2020
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Described herein are antiviral silencing RNA molecules (siRNAs), pharmaceutical compositions comprising same and uses thereof for the treatment of viral infections. In embodiments the siRNAs comprises chemically modification(s) for enhanced cell penetrating abilities and/or for greater nuclease resistance. Examples of chemical modifications include substituting one or more nucleotides of a native siRNA molecule with 2′-O-Methylnucleoside, 2′-Fluoronucleoside, aminoalkyl-nucleotide, aminoethyl-nucleotide, and/or 5′-aminopropyl-2′-OMe-nucleoside. The chemically modified nucleotides may be incorporated into the P strand, the G strand or both. Other possible modifications include coupling a compound such as a spermine molecule to the 5′ terminus or the 3′ terminus of the siRNA.
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