NON-STOP PRODUCTION PROCESS FOR IMPROVING FREEZE-DRYING SURVIVAL, HEAT TOLERANCE, SHELF STABILITY AND DIGESTIVE STABILITY OF PROBIOTICS USING SPONTANEOUS MATRIX-ENCAPSULATION TECHNIQUE

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United States of America Patent

APP PUB NO 20230320991A1
SERIAL NO

18332726

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Abstract

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Disclosed is a process for non-stop production of encapsulated probiotics, in which an alginate hydrogel is spontaneously formed through a simple process of culturing probiotics in a medium containing an alginate, a salt that forms a hydrogel by binding to alginic acid, preferably an insoluble carbonate, and optionally an encapsulation enhancer, and probiotics are encapsulated by the alginate hydrogel, thereby not only greatly improving the probiotic encapsulation process but also remarkably improving the freeze-drying viability, heat tolerance, shelf stability, and in-vivo stability (acid resistance and bile resistance) of probiotics.

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Patent Owner(s)

Patent OwnerAddress
ILDONG PHARMACEUTICAL CO LTD06752 서울특별시 서초구 바우뫼로27길 2 SEOUL 06752

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
HAN, Chi-Young Gyeonggi-do, KR 1 0
KIM, Hyeong-Eun Gyeonggi-do, KR 1 0
KIM, Tae-Yoon Gyeonggi-do, KR 95 522
KIM, Young-Hoo Gyeonggi-do, KR 50 1899
LEE, Sunghee Gyeonggi-do, KR 40 196
SEO, Han Sol Gyeonggi-do, KR 16 133

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