METHODS FOR SCREENING COMPOUNDS FOR BACTERICIDAL ACTIVITY AND FOR DETERMINING THE SENSITIVITY OF BACTERIAL SAMPLES
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United States of America Patent
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Sep 28, 2023
app pub date -
Aug 2, 2021
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Jul 31, 2020
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Abstract
The present invention relates to a method for screening compounds for bactericidal activity using thermostable luciferase and based on a real-time bioluminescence measurement. The present invention further relates to a method for determining the sensitivity of a bacterial sample originating from a subject suffering from a bacterial infection to a group of known antibiotics and to a method for assessing the minimum inhibitory concentration (MIC) of a bactericidal compound.
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