METHOD OF ENHANCING 5-HYDROXYTRYPTOPHAN (5-HTP) EXPOSURE
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United States of America Patent
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Issued Date -
Sep 28, 2023
app pub date -
Jan 27, 2023
filing date -
Jul 30, 2021
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Abstract
A gastroretentive, sustained-release dosage form including 5-hydroxytryptophan (5-HTP) as an active ingredient and low-dose carbidopa is described. For example, the dosage form can be provided as a bilayer tablet comprising a swelling layer and a modified release layer, where the 5-HTP and carbidopa are both included in the modified release layer. The dosage form provides for essentially parallel release of the 5-HTP and the carbidopa with, for instance, release of 80% of the 5-HTP and carbidopa at about 5 hours to about 12 hours. Methods of elevating 5-HTP plasma exposure are also described.
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