PYRIDOPYRIMIDINONE DERIVATIVES AS AHR ANTAGONISTS
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United States of America Patent
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Issued Date -
Sep 21, 2023
app pub date -
Nov 20, 2020
filing date -
Nov 22, 2019
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Abstract
The present disclosure relates to compounds of formula (Ia) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling. These compounds may also be useful in treating cancer when administered in combination with at least one additional therapy.
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