ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF

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United States of America Patent

APP PUB NO 20230286945A1
SERIAL NO

17990133

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

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Patent OwnerAddress
BIOSPLICE THERAPEUTICS INC9360 TOWNE CENTRE DRIVE SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bollu, Venkataiah San Diego, US 32 329
Cao, Jianguo San Diego, US 108 2882
Chiruta, Chandramouli San Diego, US 68 2008
Eastman, Brian Walter San Diego, US 22 81
KC, Sunil Kumar San Diego, US 132 3169
Mak, Chi Ching San Diego, US 42 852
Mittapalli, Gopi Kumar San Diego, US 29 179

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