RAMP TAG FOR INSULIN OVEREXPRESSION AND METHOD FOR MANUFACTURING INSULIN USING SAME
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United States of America Patent
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Aug 31, 2023
app pub date -
Dec 27, 2019
filing date -
Dec 31, 2018
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Abstract
The present invention relates to a ramp tag for insulin overexpression represented by an amino acid sequence of RGSX1GGX2R (wherein, X1 means any amino acids in the number of 0-8, and X2 means S or T) and a method for manufacturing insulin, in which the ramp tag is applied, and when the ramp tag according to the present invention is used, in the process of manufacturing recombinant proteins, without changing the ORF sequence, such as the codon optimization method, translation efficiency of insulin is increased, thereby providing the effect of remarkably increasing the expression amount of insulin.
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