AMUC-1100 POLYPEPTIDE VARIANTS FOR EFFECTING IMMUNE SIGNALLING AND/OR AFFECTING INTESTINAL BARRIER FUNCTION AND/OR MODULATING METABOLIC STATUS

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United States of America Patent

APP PUB NO 20230265131A1
SERIAL NO

18003974

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Polypeptide variants of an extracellular polypeptide of Akkermansia muciniphila are provided that are capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide variants or host cells comprising such polypeptide variants may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.

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Patent Owner(s)

Patent OwnerAddress
ADVANCED MICROBIOME INTERVENTIONS B VKROOSWIJKHOF 108 AMSTERDAM 1082 PB

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, Vos Willem Meindert Amstedam, NL 38 193
Swarts, Daniël Christianus Bennekom, NL 4 13
Tytgat, Hanne Lore Paula Zurich, CH 1 0

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