AMUC-1100 POLYPEPTIDE VARIANTS FOR EFFECTING IMMUNE SIGNALLING AND/OR AFFECTING INTESTINAL BARRIER FUNCTION AND/OR MODULATING METABOLIC STATUS
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United States of America Patent
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Aug 24, 2023
app pub date -
Jun 21, 2021
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Jul 1, 2020
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Abstract
Polypeptide variants of an extracellular polypeptide of Akkermansia muciniphila are provided that are capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide variants or host cells comprising such polypeptide variants may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.
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