STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF

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United States of America Patent

APP PUB NO 20230263887A1
SERIAL NO

18182097

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. In some embodiments the formulations of the invention comprise between 5-200 mg/mL anti-PD-1 antibody, or antigen binding fragment thereof. The invention further provides methods for treating various cancers with stable formulations of the invention. In some embodiments of the methods of the invention, the formulations are administered to a subject by intravenous or subcutaneous administration.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Basarkar, Ashwin Keasbey, US 6 20
Benjamin, Wendy North Brunswick, US 4 6
Bhattacharya, Soumendu East Windsor, US 14 113
Forrest,, Jr William P Middletown, US 6 10
Kashi, Ramesh S Warren, US 14 62
Krishnamachari, Yogita Scotch Plains, US 13 46
Mittal, Sarita Bridgewater, US 4 14
Narasimhan, Chakravarthy Nachu Scotch Plains, US 14 109
Shameem, Mohammed Nanuet, US 18 273
Sharma, Manoj K Littleton, US 8 350

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